Menu
Log in


Log in

MEMBER LOGIN

The basic immunology of asthma

Wed, October 16, 2024 1:00 PM | Anonymous
In many asthmatics, chronic airway inflammation is driven by IL-4-, IL-5-, and IL-13-producing Th2 cells or ILC2s. Type 2 cytokines promote hallmark features of the disease such as eosinophilia, mucus hypersecretion, bronchial hyperresponsiveness (BHR), IgE production, and susceptibility to exacerbations. However, only half the asthmatics have this ‘‘type 2-high’’ signature, and ‘‘type 2-low’’ asthma is more associated with obesity, presence of neutrophils, and unresponsiveness to corticosteroids, the mainstay asthma therapy. Here, we review the underlying immunological basis of various asthma endotypes by discussing results obtained from animal studies as well as results generated in clinical studies targeting specific immune pathways.

https://www.cell.com/cell/pdf/S0092-8674(21)00166-5.pdf

CHICAGO ASTHMA CONSORTIUM
400 E. Randolph St., Suite 3115, Chicago, IL 60601
Phone: 888-268-8334 Fax: 312-540-9900

Information contained on this website is provided with the understanding that Chicago Asthma Consortium, this site and its services, including all of the resources provided, serve informational purposes only. Only a doctor who is treating you can provide you with medical advice, examination, diagnosis or treatment. If you think you may have a medical emergency, call your doctor or 911 immediately. The Chicago Asthma Consortium does not endorse any medical or professional services referred to on this site or any links to this site. It also does not recommend or endorse any specific tests, products, procedures, opinions, or any other information that may be mentioned. While we try to keep the information on this site accurate, we cannot guarantee its accuracy, timeliness or completeness.

© 2023 Chicago Asthma Consortium

Powered by Wild Apricot Membership Software